Biginelli Reaction under Microwave Irradiation Conditions without a Solvent

摘要

Scientific interest in 3,4-dihydropyrimidinethiones,structural analogs of 1,4-dihydropyridines,steadily grows in view of their potential biological activity [1].The Biginelli reaction is a well-studied process,but its principal disadvantage is a long reaction time.In DMF with chlorotrimethylsilane as a catalyst,this reaction completes in 2-3 days [2].In ethanol with iron(III)or nickel(II)chloride as a catalyst,this reaction proceeds for 6-8 h [3].Using ruthenium(III)chloride allows the reaction times to be decreased to 30 min[4].