Synthesis of Bis(trimethylsilyl) Pyrid-3-yl(trimethylsiloxy)-methylphosphonite and Its Derivatives

摘要

The aryl-substituted trimethylsilyl methylphos-phonites that we have prepared earlier [1] are key compounds in the synthesis of various functionalized hydroxymethylphosphinates, which are of interest as potential ligands and biologically active substances [2]. In the present work we developed a convenient method of synthesis of pyrid-3-yl-substituted trimethyl-siloxymethylphosphonite (I) and its derivatives including pyridine fragments along with hydroxyl-methyl groups. Thus, phosphonite I was obtained in high yield in a reaction of bis(trimethylsiloxy) phosphine with pyridine-3-carbaldehyde followed by reaction of adduct A with bis(trimethylsilyl)amine (cf. [1]).