Synthesis of 3(5)-Amino-4-acylamino-5(3)-arylsulfanylpyrazoles and Their Fused Derivatives on the Basis of N-(2,2,2-Trichloro-l-hydroxyethyl)benzamides

摘要

Addition products of carboxylic acid amides and trichloroacetaldehyde are readily converted into 3-arylsulfanyl-2-acylamino-3-chloroacrylonitriles which react with hydrazine hydrate to afford 3(5)-amino-5(3)-arylsulfanyl-4-acylaminopyrazoles.The presence of an amidine fragment in the latter makes them capable of undergoing cyclocondensations with beta-dicarbonyl compounds and ethyl cyanoacetate.