Palladium-Catalyzed Isocyanide Insertion with Allylic Esters: Synthesis of N-(But-2-enoyl)-N-(tert-butyl)benzamide Derivatives via Intramolecular Acyl Transfer Termination

摘要

A novel and unprecedented intramolecular acyl transfer reaction via the palladium-catalyzed insertion of isocyanide has been established. Isocyanides were inserted into C-O bond under mild conditions, using the readily available allyl ester as the starting materials. In addition, the intramolecular acyl transfer from the ester group oxygen atom to the isocyanide nitrogen atom afforded imide derivatives in moderate to excellent yields. Additionally, this transformation was validated as having operationally simple conditions and excellent functional group compatibility.