4-Alkyl-6-amino-4-N~3,N~5-diaryl-2-thioxo-1,2,3,4- tetrahydropyridine-3,5-dicarboxamides: L Tandem Synthesis and Alkylation. Molecular and Crystal Structure of 6-AUylsulfanyl-2-amino-4-isobutyl-N~3,N~5-di-m-tolyl-3,4- dihydropyridine-3,5-dicarboxamide

摘要

4-Alkyl-6-amino-4-N~3,N~5-diaryl-2-thioxo-1,2,3,4-tetrahydropyridine-3,5-dicarboxamides were obtained via tandem synthesis involving the Knoevenagel reaction, Michael reaction and intramolecular condensation. Alkylation of the obtained dicarboxamides proceeds regioselectively at the S atom to form the corresponding thioethers. Structure of 6-allylsulfanyl-2-amino-4-isobutyl-N~3,N~5-di-m-tolyl-3,4-dihydropyridine-3,5-dicarbox-amide was uniquely determined by XRD analysis.