Mathematic Modelling to Optimize the Obtaining Process of New Thiosemicarbazides Derived from N-(P-Nitrobenzoyl)-D,L-Phenylalanine

摘要

The optimal conditions for the reaction of N-(p-nitrobenzoyl)-D;L-phenylalanine-hydrazide with aromatic isothiocianateswere established, in order to obtain new thiosemicarbazides 1,4-disubstituted with biological activity. The reaction yield was chosen as optimization factor. Temperature and reaction time were considered as being significant factors influencing the reaction yield. Factorial experiments were organized for each reaction and the reaction yield was determined for various values of reaction time and temperature. Elemental and spectral (FTIR and ~1H NMR) analyses were made in order to confirm the structure of the reaction products. Mathematic models for the reactions' yield were obtained on the basis of factorial experiments. Finally, the values of the significant factors (reaction time and temperature) corresponding to the maximum yield of reaction were established.