Synthesis of 3-R-1,5-dinitro-3-azabicyclo[3.3.1]nonanes fused to azoles

摘要

3-R-1,5-Dinitro-3-azabicyclo[3.3.1]nonanes fused to the pyrazole, thiazole, and triazole rings were synthesized by reductive cyclization of meta-dinitrobenzazoles.The present study is a continuation of our research on the development of methods for the synthesis of poly-cyclic fused heterosystems based on five-membered aromatic 4,6-dinitrobenzannulated heterocycles via the annulation of additional heterocycles using the ability of the starting dinitrobicyclic compounds to form σ~H adducts with nucleophilic reagents.