3.3.1 Synthesis of the bicyclo3.3.1nonane structure

摘要

According to the present invention, bicyclo [3.3.1 is efficiently carried out by a single operation of heating 2 equivalents of ethyl acetoacetate to alpha, beta-unsaturated aldehyde compound using t -butanol as a solvent under potassium t -butoxide base. ] Nonane structural compounds are prepared, and 3-keto-bicyclo [3.3.1] nonan-1-ol structural compounds are prepared by hydrolysis under basic aqueous solution of the compound (preferably 1M NaOH). Is provided. According to the method of the present invention, bicyclo [3.3.1] nonane compounds having various substituents can be obtained in high yield because the reaction proceeds under economical and mild conditions using inexpensive and easy to purchase reactants.;In the formula, R represents hydrogen or carboethoxy (CO ₂ Et), and R ₁ and R ₂ are each independently selected from the group consisting of hydrogen, lower alkyl having 1 to 5 carbon atoms or aryl having 10 or less carbon atoms.