Synthesis of β-D-galactopyranosylamine derivatives with the terminal amino group in the spacer as mono-, di-, and trivalent ligands of galectins

摘要

Glycoclusters were obtained by N-alkylation of N-glycyl-β-D-galactopyranosylamine with N-chloroacetyl derivatives of β-D-galactopyranosylamine and N,N"-immodiacetyl-di-β-D-galactopyranosylamine. The glycoclusters with two and three galactopyranosylamine residues and the monovalent ligand N-diglycyl-β-D-galactopyranosylamine with an amino group in the spacer are suitable for subsequent conjugation with carboxyl-containing physiologically active compounds.