Reagents for addressed modification of biopolymers 11.~* The synthesis of N~Im-2,4-dinitrophenyl derivatives of histidine and urocanic and imidazolylacetic acids for anchoring imidazole residues to oligonucleotides

摘要

Derivatives of histidine, imidazolylacetic and urocanic acids, containing an N~Im-2,4-dinitrophenyl moiety and a hydroxy group were synthesized and characterized. The applicability of these reagents for anchoring imidazole residues to oligonucleotides to give potential site-specific artificial ribonucleases was shown taking the synthesis of dinucleotide derivatives as an example.