Synthesis of 1-hetaryl-5,6-dihydropyrrolo[2,1-a]isoquinolines from 1-hetarylmethyl-3,4-dihydroisoquinolines and 1,1,1-trifluoro-3-nitrobut-2-ene

摘要

1-Hetarylmethyl-3,4-dihydroisoquinolines and their crown-containing derivatives reacted with 1,1,1-trifluoro-3-nitrobut-2-ene upon reflux in isobutanol or in toluene at room temperature to form 1-hetaryl-5,6-dihydropyrrolo[2,1-a]isoquinolines, including those with the benzocrown ether fragments.