A smart magnetic nanosystem with controllable drug release and hyperthermia for potential cancer therapy

摘要

We have successfully constructed a smart therapeutic platform with potential controllable drug release and magnetic hyperthermia through the conjugation of carboxyl-modified DNA(20) onto aminated magnetic mesoporous silica nanoparticles (MMSNs). Drug release behavior, magnetic heating capacity, in vitro cytotoxicity, and cell uptake of the magnetic nanosystem were evaluated. The results showed that the magnetic nanosystem could control the doxorubicin (DOX) release behavior with a reversible temperature response. Also, the MMSN-NH2 nanoparticles could efficiently generate heat upon exposure to an alternating magnetic field due to their superparamagnetic behavior. Furthermore, the MMSN-NH2 nanoparticles could be effectively taken up by HeLa cells, and negligible cytotoxicity has been observed for the MMSN-NH2 nanoparticles. Therefore, this magnetic nanosystem has potential for cancer therapy with controlled drug release and magnetic hyperthermia.