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首页> 外文期刊>Rheumatology >Tissue production of pro-inflammatory cytokines (IL-1beta, TNFalpha and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis.
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Tissue production of pro-inflammatory cytokines (IL-1beta, TNFalpha and IL-6) correlates with the intensity of the systemic inflammatory response and with corticosteroid requirements in giant-cell arteritis.

机译：炎性细胞因子（IL-1beta，TNFalpha和IL-6）的组织产生与全身炎性反应的强度以及巨细胞性动脉炎中皮质类固醇的需求有关。

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OBJECTIVES: To investigate proinflammatory cytokine expression in temporal arteries from patients with giant-cell arteritis (GCA) and to analyse its relationship with the intensity of the initial systemic inflammatory reaction and response to corticosteroid therapy. METHODS: Quantification of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNFalpha), and interleukin-6 (IL-6) mRNA by real-time quantitative PCR in temporal artery samples from 36 patients with biopsy-proven GCA and 11 controls. Immunohistochemical detection of IL-1beta, TNFalpha, and IL-6 in temporal artery sections from 74 patients with GCA and 15 controls. Clinical and biochemical parameters of inflammation as well as the time (weeks) required to reach a maintenance prednisone dose <10 mg/day were recorded. RESULTS: IL-1beta (13.8 +/- 2.5 vs 5.4 +/- 1.3 relative units, P = 0.012) and IL-6 transcripts (34 +/- 13.7 vs 7.8 +/- 4.5 relative units, P = 0.034) were significantly more abundant in patients with a strong systemic inflammatory response compared with those with no inflammatory parameters. Immunohistochemical scores for IL-1beta (2.7 +/- 0.3 vs 1.9 +/- 0.2, P = 0.018), TNFalpha (3.2 +/- 0.2 vs 2.4 +/- 0.3, P = 0.028) and IL-6 (3 +/- 0.2 vs 2.1 +/- 0.3, P = 0.023) were also significantly higher in patients with strong systemic inflammatory reaction. A significant correlation was found between the amount of tissue TNFalpha mRNA and the time required to reach a maintenance dose of prednisone <10 mg/day (r = 0.586, P = 0.001). CONCLUSION: GCA patients with a strong systemic inflammatory response, who have been previously shown to be more resistant to corticosteroid therapy, have elevated tissue expression of proinflammatory cytokines IL-1beta, TNFalpha and IL-6. High production of TNFalpha is associated with longer corticosteroid requirements.
机译：目的：调查巨细胞性动脉炎（GCA）患者颞动脉中促炎细胞因子的表达，并分析其与初始全身炎症反应强度和对皮质类固醇激素治疗反应的关系。方法：通过实时定量PCR对36例经活检证实的GCA和GCA患者的颞动脉样品中白细胞介素1β（IL-1beta），肿瘤坏死因子α（TNFalpha）和白细胞介素6（IL-6）mRNA的定量分析。 11个控件。 74名GCA患者和15名对照的颞动脉切片中IL-1beta，TNFα和IL-6的免疫组织化学检测。记录炎症的临床和生化参数，以及达到维持泼尼松剂量<10 mg /天所需的时间（周）。结果：IL-1beta（13.8 +/- 2.5 vs 5.4 +/- 1.3相对单位，P = 0.012）和IL-6成绩单（34 +/- 13.7 vs 7.8 +/- 4.5相对单位，P = 0.034）显着与没有炎症参数的患者相比，具有强烈全身性炎症反应的患者的肝素含量更高。 IL-1beta（2.7 +/- 0.3 vs 1.9 +/- 0.2，P = 0.018），TNFalpha（3.2 +/- 0.2 vs 2.4 +/- 0.3，P = 0.028）和IL-6（3 + /的免疫组织化学评分-系统性炎症反应强烈的患者，其0.2 vs 2.1 +/- 0.3，P = 0.023）也明显更高。发现组织TNFαmRNA的量与达到维持剂量泼尼松<10 mg /天所需的时间之间存在显着相关性（r = 0.586，P = 0.001）。结论：先前已显示出对皮质类固醇疗法具有更高抵抗力的，具有强烈全身炎症反应的GCA患者，其促炎细胞因子IL-1beta，TNFalpha和IL-6的组织表达升高。 TNFα的高产量与更长的皮质类固醇需求有关。

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