Method for inhibiting a pro-inflammatory response from a mononuclear cell and polymorphonuclear cell from human peripheral blood, or a fixed tissue cell, when contacted with a pro-inflammatory agent, receptor complex, and, method for the identification of a g kinase protein signal pathway modifying agent

摘要

"METHOD FOR THE INHIBITION OF A PRO-INFLAMMATORY RESPONSE TO A MONUMENTAL CELL AND HUMAN PERIPHERAL BLOOD POLYMORPHONUCLEAR CELL, OR A FIXED TISSUE CELL, WHEN CONTACTED WITH A PRO-INFLAMMATORY, COMPLEX, AGENT AND COMPETENT AGENT AN AGENT OF MODIFICATION OF THE PROTEIN G KINASE SIGNAL ROUTE ". A method for inhibiting a pro-inflammatory response and a human peripheral blood mononuclear cell or polymorphonuclear cell or fixed tissue cell is described. The cell is relied on a pro-inflammatory agent to stimulate the pro-inflammatory response. Then, the cell is contacted with a protein G kinase signal pathway modifying agent, thereby inhibiting G protein-mediated inflammatory response signal transduction pathways. A receptor complex is described in which a pathway modifying agent of protein G kinase signal binds to a cell surface receptor of a mononuclear cell and a human peripheral blood polymorphonuclear cell that has been stimulated by a pro-inflammatory agent.