Bronchoconstriction induced by inhaled methacholine delays desflurane uptake and elimination in a piglet model

摘要

Bronchoconstriction is a hallmark of asthma and impairs gas exchange. We hypothesized that pharmacoldnetics of volatile anesthetics would be affected by bronchoconstriction. Ventilation! perfusion (V-A/Q) ratios and pharmacokinetics of desflurane in both healthy state and during inhalational administration of methacholine (MCh) to double peak airway pressure were studied in a piglet model.