Changes of porous poly(epsilon-caprolactone) bone grafts resulted from e-beam sterilization process

摘要

The most important mechanical feature of poly(e-caprolactone) (PCL) foams applied in bone tissue engineering as a scaffold,has been investigated as a function of irradiation dose.Radiation is proposed for the sterilization of the polymer before the implantation.Polycaprolactone scaffold foams were obtained by combination of compression molding and particulate leaching techniques.The porogen was changed in the range 74-96 w% and the irradiation dose was varied from 25 to 150kGy.Our results show that yield strength is not a function of radiation dose,but is rather influenced by the porosity,while the critical strain is mainly dependent on the dose.All these together mean that the modulus of the elasticity of PCL foams is dependent on both the porosity and the dose.