Evaluation of internal occupational exposure by I-123 in a radiopharmaceutical production facility

摘要

I-123 is a photon emitter radionuclide (159 key) used for diagnostic procedures of endocrinal diseases in nuclear medicine. Since 1998 it is produced at the industrial radiopharmaceutical plant operated by the Institute for Nuclear Energy (IEN-CNEN) and supplied to clinics located in the State of Rio de Janeiro, in Brazil. The production of this radionuclide represents a risk of internal occupational exposure. According to international recommendations, workers involved in this activity should be routinely monitored in order to comply with dose limits and keep individual exposures as low and reasonably achievable. The Radiation Protection Plan implemented at the IEN includes annual in vivo measurements of I-123 in the thyroid performed at the In Vivo Monitoring Laboratory of the Institute for Radiation Protection and Dosimetry (IRD-CNEN). This work describes a series of improvements on the measurement techniques used for the monitoring of the workers from the facility, including (i) optimization of in vivo measurement of the thyroid using an array of high-purity germanium detectors, (ii) development of a new in vitro bioassay method for the determination of I-123 in urine samples using a HPGe germanium detector and (iii) the establishment of a methodology for internal dose assessment, based on bioassay data. The sensitivity of the methods allow detection of I-123 activities below derived registry level of 1 mSv for the incorporation scenarios of exposure assumed in this work. Thus, it can be concluded that the methods are suitable for application in routine monitoring of workers occupationally exposed to I-123 in this facility. (C) 2014 Elsevier Ltd. All rights reserved.