Radiodiagnosis of Peptic Ulcer with Technetium-99m Labeled Rabeprazole

摘要

Rabeprazole, antiulcer drug, was labeled with ~(99m)Tc to obtain an agent for ulcer imaging. The radiochemical yield of ~(99m)Tc-rabeprazole reaches approximately 98.5 ± 0.4%. The optimum conditions are as follows: pH 9, 50 μg of SnCl_2·2H_2O, 30 min, and 3 mg of the substrate. ~(99m)Tc-rabeprazole was stable for 6 h. Intravenous biodistribution studies of ~(99m)Tc-rabeprazole revealed high concentration in the stomach ulcer, reaching about 33.4% of the total injected dose at 30 min post injection. This concentration of ~(99m)Tc-rabeprazole in stomach ulcer makes this agent promising for stomach ulcer imaging.