Radiation-induced changes in carboxymethylated chitosan

摘要

This study focuses on the radiation effect of gamma-ray on carboxymethylated chitosan(CM-chitosan)in solid state.The changes in molecular weight of CM-chitosan with absorbed dose were monitored by viscosity method.Experimental results indicated that random chain scissions took place under irradiation.Radiation chemical yield(G_d)of CM-chitosan in solid state with N2-saturated was 0.49,which showed CM-chitosan has high radiation stability.Biomaterials composed of CM-chitosan can be thought to sterilize with low absorbed dose.FTIR and UV spectra showed that main chain structures of CM-chitosan were retained,carbonyl/carboxyl groups were formed and partial amino groups were eliminated in high absorbed dose.XRD patterns identified that the degradation of CM-chitosan occurred mostly in amorphous region.