LETTER TO THE EDITOR CR1 gene polymorphism in Finland

摘要

We read with interest the recently published article by Hodgson et al. reporting a lack of association between idiopathic pulmonary fibrosis and the complement receptor 1 (CR1) gene C5507G polymorphism among a series of Finnish patients. This evidence contrasts with our research group's previous report, showing an association between polymorphisms and this disease in an Italian series of patients. Moreover, based on their results, Dr. Hodgson and coworkers stated that the CR1 G5507 is not a polymorphic site in the Finnish, since the C allele was never found, either among patients or among controls. Since we noticed that Dr. Hodgson and coworkers used a markedly different methodology than that described by Zorzetto et al. we decided to conduct a comparative experiment.