Bone mineral density in children with non-cystic fibrosis bronchiectasis.

摘要

BACKGROUND: Bronchiectasis presents as a common sequela of several chronic pulmonary diseases. Bone mineral density (BMD) is generally decreased in children with cystic fibrosis (CF). Although children with non-CF bronchiectasis have similar risk factors for osteopenia/osteoporosis, data on BMD in this group of patients are lacking. OBJECTIVE: To evaluate BMD in children with non-CF bronchiectasis. METHODS: In this study, we evaluated BMD of the radius and tibia in 32 children (17 girls) with non-CF bronchiectasis and in 23 healthy controls matched for age, sex and pubertal stage by quantitative ultrasound (speed of sound). Daily calcium intake and pulmonary function tests and data about steroid use were noted. RESULTS: Mean age was 12.5 +/- 4.6 years. Six children (18%) had moderate-to-severe lung disease (FEV(1) <60% predicted). All except 2 children (94%) were receiving inhaled steroids. There was no significant difference in BMD (expressed as z-score) of the radius and tibia between the patient andcontrol groups (tibia z-scores: -0.1 +/- 0.9 vs. -0.8 +/- 0.8 and radius z-scores -1.3 +/- 1.4 vs. -1.0 +/- 0.9 in bronchiectasis patients and controls, respectively, p > 0.05). However, more children with non-CF bronchiectasis had osteopenia (z-scores between -1 and -2 SD) and osteoporosis (z-score