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Vitreous hemorrhage complicating intravitreal tissue plasminogen activator and pneumatic displacement of submacular hemorrhage.

机译:玻璃体出血使玻璃体内组织纤溶酶原激活剂复杂化,并引起黄斑下出血的气动置换。

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PURPOSE: To evaluate the clinical factors associated with vitreous hemorrhage (VH) complicating intravitreal tissue plasminogen activator and pneumatic displacement of submacular hemorrhage, and analyze visual outcomes. METHODS: In this retrospective, comparative study, 120 consecutive eyes underwent intravitreal tissue plasminogen activator (50 mug) and perfluoropropane (0.3 mL) injection for submacular hemorrhage secondary to different causes. We recorded their demographic data, visual acuity, complications, and further treatment after VH. Two groups created according to the occurrence of VH were compared to identify possible risk factors. RESULTS: Breakthrough VH occurred in 18 eyes (15%). The size of submacular hemorrhage was significantly positively related to the occurrence of VH (P for trend <0.001). Among etiology, idiopathic polypoidal choroidal vasculopathy (IPCV) was associated with a significantly higher incidence of VH (odds ratio, 15.63; 95% confidence interval, 2.30-106.15; P = 0.005). Age-related macular degeneration was much less likely than other causes to result in VH (odds ratio, 0.121; 95% confidence interval, 0.023-0.642; P = 0.013). Best and final visual acuity improved significantly from initial visual acuity in both groups (P < 0.05). CONCLUSION: A large area of submacular hemorrhage (>/=10 disk areas) and IPCV were risk factors for VH after injection. The occurrence of VH did not affect final visual outcome.
机译:目的:评估与玻璃体腔内组织纤溶酶原激活物和黄斑下出血的气动移位相关的玻璃体出血(VH)相关的临床因素,并分析视觉结果。方法:在这项回顾性比较研究中,连续120眼接受玻璃体内组织纤溶酶原激活剂(50马克杯)和全氟丙烷(0.3毫升)注射液治疗继发于不同原因的黄斑下出血。我们记录了他们的人口统计学数据,视敏度,并发症以及VH后的进一步治疗。比较了根据VH发生而创建的两组,以识别可能的危险因素。结果:突破性VH发生在18只眼中(15%)。黄斑下出血的大小与VH的发生呈显着正相关(趋势<0.001的P值)。在病因学中,特发性息肉样脉络膜血管病(IPCV)与VH的发生率显着较高相关(比值比为15.63; 95%置信区间为2.30-106.15; P = 0.005)。与年龄相关的黄斑变性比其他原因导致VH的可能性要小得多(优势比为0.121; 95%置信区间为0.023-0.642; P = 0.013)。两组的最佳和最终视力均较初始视力明显提高(P <0.05)。结论:大面积黄斑下出血(> / = 10个椎间盘区域)和IPCV是注射后VH的危险因素。 VH的发生不影响最终的视觉结果。

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