Design, synthesis and insecticidal activities of dihydropyridine-fused neonicotinoids compounds with trifluoromethyl group

摘要

A series of novel neonicotinoids containing a dihydro-pyridine ring and a trifluoromethyl group were designed and synthesized by multicomponent reactions of 6-Cl-PMNI, triethoxymethane and 4,4,4-trifluoro-3-oxobutaneanilides (9) under solvent-free and catalyst-free conditions. The trifluoromethyl group plays an important role as an electron-withdrawing group in enhancing the reaction activity of compound 9. The target compounds were characterized by H-1 NMR, IR and elemental analysis. Bioassays indicated that most of the synthesized compounds exhibited moderate insecticidal activities against Aphis craccivora.