Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

Lara PC; Lloret M; Clavo B; Apolinario RM; Bordon E; Rey A; Falcon O; Alonso AR; Belka C

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

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Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

机译：缺氧下调宫颈癌肿瘤组织中Ku70 / 80的表达。

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Hypoxia may inhibits the NHEJ DNA repair through downregulating Ku70/80 expression and combined with an increased angiogenesis and altered p53 expression would be responsible for tumor progression in cervical carcinoma.

机译：缺氧可能通过下调Ku70 / 80表达来抑制NHEJ DNA修复，并与增加的血管生成和改变的p53表达结合，可能是宫颈癌的肿瘤进展原因。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2008年第2期|共5页
作者
Lara PC; Lloret M; Clavo B; Apolinario RM; Bordon E; Rey A; Falcon O; Alonso AR; Belka C;
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原文格式 PDF
正文语种 eng
中图分类放射医学;肿瘤学;
关键词
Oxygen Deficiency; Cervical Cancer; angiogenesis; Neoplasm progression NOS; DNA修复;

机译：缺氧;宫颈癌;血管生成;肿瘤进展NOS;DNA修复;

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专利

1. Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors. [J] . Lara PC, Lloret M, Clavo B, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2008,第2期

机译：缺氧下调宫颈癌肿瘤组织中Ku70 / 80的表达。
2. Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression [J] . Jingjing Li, Haiwen Li, Dechao Zhan, Journal of Cancer . 2018,第4期

机译：Niclosamide通过下调Ku70 / 80表达使鼻咽癌对放射敏感
3. Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study. [J] . Korabiowska M, Cordon Cardo C, Schinagl M, Human Pathology . 2006,第4期

机译：与散发性结直肠肿瘤相比，遗传性疾病中Ku70 / Ku80表达的丧失更为频繁。组织芯片研究。
4. The expression of EMP1 is downregulated in oral squamous cell carcinoma and possibly associated with tumour metastasis [C] . Jun Zhang, Wei Cao, Qin Xu, Academic Committee Conference of Shanghai key lab of stomatology . 2011

机译：EMP1的表达在口腔鳞状细胞癌中下调，可能与肿瘤转移有关
5. DNA end protection at double strand breaks and telomeres by Ku70/80 and Cdc13. [D] . Krasner, Danielle Sonya. 2015

机译：Ku70 / 80和Cdc13在双链断裂和端粒的DNA末端保护。
6. Niclosamide sensitizes nasopharyngeal carcinoma to radiation by downregulating Ku70/80 expression [O] . Jingjing Li, Haiwen Li, Dechao Zhan, 2018

机译：Niclosamide通过下调Ku70 / 80表达使鼻咽癌对放射敏感
7. Expression of Concern: LncRNA SRA1 is downregulated in HPV-negative cervical squamous cell carcinoma (CSCC) and regulates cancer cell behaviors [O] . 2020

机译：关注的表达：LNCRNA SRA1在HPV阴性宫颈鳞状细胞癌（CSCC）中下调并调节癌细胞行为

Hypoxia downregulates Ku70/80 expression in cervical carcinoma tumors.

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