Formulation and evaluation of mucoadhesive microcsapsules of Aceclofenac for Oral controlled release by Emulsification-gelation Technique

摘要

Microencapsulation by emulsification-ionic gelation technique is an approach to achieve controlled release of drug and mucoadhesive microcapsules were designed to improve the absorption and bioavailability of drug. Microcapsules of Aceclofenac were formulated by employing sodium alginate, two natural polymers-gum kondagogu and gum karaya. The prepared microcapsules were free flowing, discrete spherical shape was characterised by scanning electron microscopy (SEM). Microencapsulation efficiency was in the range of 60-80% and they exhibited good mucoadhesive property. Invitro dissolution data revealed that formulations exhibit the zero order kinetics and followed non-fickian diffusion transport mechanism. In-vitro release profile of formulation (F3) was found similar to that of marketed formulation. Pre-clinical pharmacological activity i.e. analgesic activity was conducted and optimized formulation exhibited the significant analgesic activity Mucoadhesive microcapsules prepared with sodium alginate, gum karaya and gum kondagogu found to be suitable for oral controlled release.