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首页> 外文期刊>Cell Biology and Toxicology >The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C.
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The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C.

机译:二嗪农对大鼠心脏脂质过氧化和抗氧化酶的影响以及改善维生素E和维生素C的作用。

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摘要

Diazinon is one of the most widely used organophosphate insecticides (OPIs) in agriculture and public health programs. Reactive oxygen species (ROS) caused by OPIs may be involved in the toxicity of various pesticides. The aim of this study was to investigate how diazinon affects lipid peroxidation (LPO) and the antioxidant defence system in vivo and the possible ameliorating role of vitamins E and C. For this purpose, experiments were done to study the effects of DI on LPO and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in adult rat heart. Experimental groups were: (1) control group, (2) diazinon treated (DI) group, (3) DI+vitamins E and C-treated (DI+Vit) group. The levels of malondialdehyde (MDA) and the activities of SOD and CAT increased significantly in the DI group compared with the control group. The activity of SOD and the levels of MDA decreased significantly in the DI+Vit group compared with the DI group. The differences between the DI+Vit and control groups according to the MDA levels and the activities of both SOD and CAT were statistically significant. These results suggest that treating rats with a single dose of diazinon increases LPO and some antioxidant enzyme activities in the rat myocardium and, in addition, that single-dose treatment with a combination of vitamins E and C after the administration of diazinon can reduce LPO caused by diazinon, though this treatment was not sufficiently effective to reduce the values to those in control group..
机译:二嗪农是农业和公共卫生计划中使用最广泛的有机磷杀虫剂(OPI)之一。由OPI引起的活性氧(ROS)可能与各种农药的毒性有关。这项研究的目的是研究二嗪农如何影响体内脂质过氧化(LPO)和抗氧化防御系统,以及维生素E和C的可能改善作用。为此,进行了实验研究DI对LPO和LPO的影响。成年大鼠心脏中的超氧化物歧化酶(SOD),谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)的活性。实验组为:(1)对照组,(2)二嗪农治疗(DI)组,(3)DI +维生素E和C治疗的(DI + Vit)组。与对照组相比,DI组的丙二醛(MDA)水平和SOD和CAT活性显着增加。与DI组相比,DI + Vit组的SOD活性和MDA含量明显降低。 DI + Vit组和对照组之间根据MDA水平以及SOD和CAT活性的差异具有统计学意义。这些结果表明,用单剂量的二嗪农处理大鼠会增加大鼠心肌中的LPO和某些抗氧化酶的活性,此外,在服用二嗪农后用维生素E和C组合单剂量治疗可减少LPO的产生。通过二嗪农,尽管这种治疗不足以将其值降低至对照组。

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