Dental caries inhibition in albino rats by Breynia nivosus extract

摘要

The study investigated the caries inductive capacities of different sucrose concentrations and the anti-canes acfivity of Breynia nivosus extract in experimental albino rats. Different concentrations (70, 50, 30 and 10%) of sucrose-in-diet, were respectively fed to caries-free albino rats harboring Streprococcus rattus in their oral cavity, to determine their caries induction effect. Subsequently, 200 mg mL~(-1) of Breynia nivosus extract were intraorally administered to the teeth surfaces of caries-free and non carries free rats to ascertain its possible caries curative and/or preventive effects. Direct obsenration, probing, microbial count and radiography were used to monitor the caries status of the rats. There were significant increase (p<0.05) in the microbial count of dental plaque of rat groups fed with 70, 50 and 30% sucrose-in-diet However, milky, white spots were only observed among the rat groups fed with 70 and 50% sucrose-in-diet at the 6th week of observation. The results of this investigation suggests that Breynia nivosus extract possesses some degree of in vivo caries preventive and curative effect on the teeth surfaces of albino rats fed simultaneously with 70% sucrose-in-diet.