Dental Caries Inhibition in Albino Rats by Breynia nivosus Extract

摘要

The study investigated the caries inductive capacities of different sucrose concentrations and the anti-caries activity of Breynia nivosus extract in experimental albino rats. Different concentrations (70, 50, 30 and 10%) of sucrose-in-diet, were respectively fed to caries-free albino rats harboring Streptococcus rattus in their oral cavity, to determine their caries induction effect. Subsequently, 200 mg mL~-1 of Breynia nivosus extract were intra-orally administered to the teeth surfaces of caries-free and non caries free rats to ascertain its possible caries curative and/or preventive effects. Direct observation, probing, microbial count and radiography were used to monitor the caries status of the rats. There were significant increase (p<0.05) in the microbial count of dental plaque of rat groups fed with 70,50 and 30% sucrose-in-diet. However, milky white spots were only observed among the rat groups fed with 70 and 50% sucrose-in-diet at the 6th week of observation. The results of this investigation