Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays

摘要

There is a pressing need for non-animal methods to predict skin sensitisation potential and a number of in chemico and in vitro assays have been designed with this in mind. However, some compounds can fall outside the applicability domain of these in chemico/in vitro assays and may not be predicted accurately.