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Probiotics in cirrhosis: Do we expect too much?

机译:肝硬化中的益生菌:我们期望太多吗?

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Probiotics are life micro-organisms that produce a beneficial effect to the host when administered in an adequate amount (1). Interest in probiotics has grown in recent years, partly because they are an 'ecologic', non-pharmacological and relatively cheap approach to prevent and treat a variety of diseases. The main properties underlying their beneficial effects are the ability to modify the intestinal microbiota, to improve the intestinal barrier and to modulate inflammatory response. With these properties, the potential areas of applicability are wide (1, 2). Evidence for their usefulness is still low, however, and mainly limited to only a few entities, such as necrotizing enterocolitis and acute infectious diarrhoea in children, and antibiotic-associated diarrhoea, pouchitis and lactose maldigestion in adults (1).
机译:益生菌是生命微生物,当以足够的量施用时会对宿主产生有益的作用(1)。近年来,人们对益生菌的兴趣有所增长,部分原因是它们是预防和治疗多种疾病的“生态”,非药理和相对便宜的方法。它们有益作用的主要特性是修饰肠道菌群,改善肠道屏障和调节炎症反应的能力。凭借这些特性,潜在的适用范围很广(1、2)。然而,其有用性的证据仍然很低,并且主要限于少数实体,例如儿童坏死性小肠结肠炎和急性感染性腹泻,以及成年人的抗生素相关性腹泻,囊袋炎和乳糖消化不良(1)。

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