Aminocarbonylation of aryl halides using surfactant in water-a greener approach

摘要

An environmentally benign,very efficient,highly selective and practically scalable aminocarbonylation of various aryl halides with different alkyl/aryl amines is developed using a surfactant in water.The reactions proceed by palladium catalysis using solid W(CO)6 as the CO source with non-inert conditions,in water using TPGS-750 M as a surfactant.The methodology developed is elaborated into lactam synthesis and applicable to biologically important substances as well.