Der Hering-Breuer-Reflex bei künstlicher Beatmung des Kaninchens

摘要

1.Anesthetized, non-curarized rabbits were artificially ventilated at such high rate and small inflation volume that the inspirations no longer closely followed upon the deflation phases of the respirator.2.In this condition the medulla oblongata was electrically stimulated. One volley of repetitive stimuli per cycle of the respirator (inflation and deflation) was applied, the volleys lasting 1/6th of one cycle's duration. When certain points were stimulated the inspirations closely followed upon the combined artificial ventilation and bulbar stimulation.3.100 and 150 impulses per second proved to be optimal to elicit the inspirations, whereas 20 impulses per second were ineffective.4.The influence of bulbar stimulation with 100 impulses per second upon the spontaneous respiration was examined, the parameters being the same as in combined artificial ventilation and stimulation. In and expiratory effects occurred. When certain points were stimulated the inspirations closely followed upon the stimulus volleys.5.At some points inspirations could only be elicited by combined artificial ventilation and bulbar stimulation. At other points the threshold voltage was lower in combined ventilation and central stimulation than in stimulation alone. Results suggest that during certain phases artificial ventilation exerts an inspiration-facilitating influence upon the bulbar reticular formation.