A new approach to the synthesis of lysophospholipids:preparation of lysophosphatidic acid and lysophosphatidylcholine from p-nitrophenyl glycerate

摘要

A new stereospecific synthesis of lysophosphatidic acid and lysophosphatidylcholine is reported.The sequence relies on p-nitrophenyl-D-glycerate as a chiral synthon,including chemoselective reduction of the active ester function without affecting other carboxylic ester groups present in the molecule.