Mantle cell lymphoma in a mother and her daughter.

摘要

Mantle cell lymphoma (MCL) was reported to be another potential familial lymphoproliferative disease for the first time in 2004 [1]. Since then, no similar cases have been reported. Here we describe a familial MCL first occurring in the pattern of mother and daughter. A 45-year-old female presented with colonic polyposis and was initially diagnosed with inflammatory bowel disease. After 2 months of mesalazine therapy, the related symptoms were not reduced. Subsequently, a right elbow lymph node biopsy showed lymphadenosis positive for MUM-1, Bcl-2, CD79a, p53, Bcl-6, and cyclin D1, and negative for CD3, CD5, CD10, and CD30. Further abdominal computed tomography (CT) evaluation revealed the walls of the stomach, duodenum, distal ileum, and rectum to be significantly thickened. She was diagnosed as having MCL (stage IV), and achieved a partial response after two cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincris-tine, prednisone).