Enantioselective michael addition of malonates to aromatic α,β-unsaturated aldehydes organocatalyzed by (s)-2-[bis(3,4,5- trifluorophenyl) trimethylsilanyloxymethyl]pyrrolidine

摘要

The Michael addition of malonates to aromatic α,β-unsaturated aldehydes was efficiently organocatalyzed by (S)-2-[bis(3,4,5-trifluorophenyl) trimethylsilanyoxymethyl]pyrrolidine, derived from L-proline to afford the corresponding adducts in good yields with good to excellent enantioselectivities.