Mediterranean-style diet and intracranial large artery stenosis in the Northern Manhattan Study

摘要

? 2023Objectives: Given Mediterranean-style diet (MeDi) reduces risk of cardiovascular events, we hypothesized MeDi may also be protective against intracranial large artery stenosis (ICAS), a common cause of stroke worldwide. Methods: This cross-sectional study included stroke-free participants of the Northern Manhattan Study, a diverse population-based study of stroke risk factors. We represented MeDi continuously (range 0-8) based on enrollment food frequency questionnaires, excluding alcohol consumption. We evaluated ICAS both dichotomously at clinically relevant stenosis severities and continuously as a score (possible range 0-44), summated from stenosis severity scores of major intracranial arteries from time-of-flight magnetic resonance angiography. We used logistic or zero-inflated Poisson regression, adjusting for key confounders. Results: Among 912 included participants (mean age 64±8 years, 59 female, 65 Hispanic, mean MeDi score 4±1.5), 5 and 8 of participants had ≥50 or ≥70 ICAS, respectively (score median interquartile range: 0 0-2). Increased MeDi score was inversely associated with ICAS, but did not reach statistical significance (≥50 stenosis odds ratio (OR) 95 confidence interval (CI): 0.89 0.79-1.06; ≥70 stenosis OR 95 CI: 0.91 0.74-1.13; stenosis score β-estimate 95 CI: -0.02 -0.06-0.01). Conclusion: In this stroke-free subsample, we did not find a significant association between MeDi and ICAS. We may have been limited by statistical power.