Gene polymorphisms of interleukin 10 (-819 C/T and-1082 G/A) in women with ovarian cancer

摘要

Background: Ovarian cancer (OC) is the leading cause of death associated with gynecologic cancer. IL-10 plays an important role in tumorigenesis. We investigated IL-10 gene polymorphisms in OC patients. The current case-control study screened forty-eight women with OC and forty-eight healthy women who did not have OC. The genotyping of SNPs (- 1082 G > A; rs1800896 and - 819 C > T; rs1800871) of the IL-10 gene was done by tetra primers sequence-specific primer polymerase chain reaction (SSP-PCR) technique. The plasma levels of IL-10 were measured using an enzyme-linked immunosorbent assay (ELISA).Results : For IL-10 (- 1082 G/A) polymorphism, the G (wild allele) was significantly associated with increasing the risk of OC (OR = 2.054 with CI = 1.154-3.657; P A and - 819 C > T shows the GT haplotype was significantly associated with increasing the risk of OC (OR = 50.09 with CI = 6.34-395.92; P 0.05).Conclusions: Overall, this study supports an association of IL-10 (- 1082 G/A and - 819C/T) polymorphisms with the risk of ovarian cancer.