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首页> 外文期刊>Nutrition, metabolism, and cardiovascular diseases: NMCD >Inflammatory cytokines in insulin-treated patients with type 2 diabetes.
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Inflammatory cytokines in insulin-treated patients with type 2 diabetes.

机译：胰岛素治疗的2型糖尿病患者中的炎性细胞因子。

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OBJECTIVE: An association between type 2 diabetes mellitus and inflammation has been described in several studies. The aim of this study was to search for the presence of low-grade inflammation in a special group of insulin-treated patients with type 2 diabetes, and to investigate a possible correlation between inflammation and obesity, glucose homeostasis and insulin requirement (IU insulin/kg body weight, BW). METHODS: We studied 85 subjects with type 2 diabetes that were receiving insulin treatment (group A) and 32 receiving sulfonylurea treatment (group B), and 57 subjects without diabetes (group C). Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and the soluble TNF-alpha receptors sTNFR-60 and sTNFR-80 were measured in serum samples taken from all patients. RESULTS: The mean serum cytokine levels in group A vs. group B were: IL-6, 8.54+/-11 vs. 2.71+/-1.9 pg/ml (p=0.000); TNF-alpha, 14.33+/-24 vs. 5.12+/-15 pg/ml (p=0.016); sTNFR60, 3.9+/-2.8 vs. 2.36+/-1.4 ng/ml (p=0.000); and sTNFR80, 11.9+/-7 vs. 9.4+/-6 ng/ml (p=0.080). The mean serum cytokine levels in group A vs. group C were: IL-6, 8.54+/-11 vs. 4.74+/-7 pg/ml (p=0.017); TNF-alpha, 14.33+/-24 vs. 5.94+/-3.4 pg/ml (p=0.003); sTNFR60, 3.9+/-2.8 vs. 2.54+/-1.4 ng/ml (p=0.000); and sTNFR80, 11.9+/-7 vs. 10.85+/-8 ng/ml (p=0.470). A positive association between waist circumference and IL-6 (r=0.165, p=0.030) and sTNFR-60 (r=0.276, p=0.000) was detected. A significant correlation coefficient was observed between haemoglobin A1c (HbA1c) and both IL-6 (r=0.278, p=0.000) and sTNFR-60 (r=0.293, p=0.000), when the groups were studied as one. No correlation between inflammation and units of insulin/kg BW was found. In conclusion, low-grade chronic inflammation, as estimated by the relative levels of inflammatory cytokines, was present in patients with type 2 diabetes that were receiving insulin treatment, with significantly higher cytokine levels recorded compared to sulfonylurea-treated patients. In addition, an association between inflammation and both obesity and glucose homeostasis was detected.
机译：目的：在几项研究中已经描述了2型糖尿病与炎症之间的关联。这项研究的目的是在一组特殊的接受过胰岛素治疗的2型糖尿病患者中寻找低度炎症的存在，并研究炎症与肥胖，葡萄糖稳态和胰岛素需求（IU胰岛素/公斤体重，体重）。方法：我们研究了85位接受胰岛素治疗的2型糖尿病受试者（A组）和32位接受磺酰脲治疗的受试者（B组），以及57位无糖尿病的受试者（C组）。在所有患者的血清样本中测量了白介素-6（IL-6），肿瘤坏死因子-α（TNF-α）和可溶性TNF-α受体sTNFR-60和sTNFR-80。结果：A组与B组的平均血清细胞因子水平分别为：IL-6、8.54 +/- 11与2.71 +/- 1.9 pg / ml（p = 0.000）; TNF-α，14.33 +/- 24与5.12 +/- 15 pg / ml（p = 0.016）; sTNFR60，3.9 +/- 2.8对2.36 +/- 1.4 ng / ml（p = 0.000）;和sTNFR80，分别为11.9 +/- 7和9.4 +/- 6 ng / ml（p = 0.080）。 A组与C组的平均血清细胞因子水平分别为：IL-6、8.54 +/- 11与4.74 +/- 7 pg / ml（p = 0.017）; TNF-α，14.33 +/- 24与5.94 +/- 3.4 pg / ml（p = 0.003）; sTNFR60，3.9 +/- 2.8与2.54 +/- 1.4 ng / ml（p = 0.000）;和sTNFR80，分别为11.9 +/- 7和10.85 +/- 8 ng / ml（p = 0.470）。检测到腰围与IL-6（r = 0.165，p = 0.030）和sTNFR-60（r = 0.276，p = 0.000）之间呈正相关。在将血红蛋白A1c（HbA1c）与IL-6（r = 0.278，p = 0.000）和sTNFR-60（r = 0.293，p = 0.000）一起观察时，观察到显着的相关系数。没有发现炎症与胰岛素/千克体重的单位之间存在相关性。总之，接受胰岛素治疗的2型糖尿病患者存在以炎症细胞因子相对水平评估的轻度慢性炎症，与磺酰脲治疗的患者相比，细胞因子水平明显更高。另外，还检测到炎症与肥胖症和葡萄糖稳态之间的关联。

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