Effects of anesthetics on vesicular monoamine transporter type 2 binding to F-18-FP-(+)-DTBZ: a biodistribution study in rat brain

摘要

Objectives: The in vivo binding analysis of vesicular monoamine transporter type 2 (VMAT2) to radioligand has provided a means of investigating related disorders. Anesthesia is often inevitable when the investigations are performed in animals. In the present study, we tested effects of four commonly-used anesthetics: isoflurane, pentobarbital, chloral hydrate and ketamine, on in vivo VMAT2 binding to F-18-FP-(+)-DTBZ, a specific VMAT2 radioligand, in rat brain.