Preclinical and clinical evaluation of O-[C-11]methyl-L-tyrosine for tumor imaging by positron emission tomography

摘要

We performed preclinical and clinical studies of O-[C-11]methyl-L-tyrosine, a potential tracer for imaging amino acid transport Of tumors by positron emission tomography (PET). Examinations of the radiation-absorbed dose by O-[C-11]methyl-L-tyrosine and the acute toxicity and mutagenicity of O-methyl-L-tyrosine showed suitability of the tracer for clinical use. The whole-body imaging of monkeys and healthy humans by PET showed low uptake of O-[C-11]methyl-L-tyrosine in all normal organs except for the urinary track and bladder, suggesting that the O-[C-11]methyl-L-tyrosine PET has the potential for tumor imaging in the whole-body. Finally, the brain tumor imaging was preliminarily demonstrated. (c) 2005 Elsevier Inc. All rights reserved.