T-Reg Comparator is a novel software tool designed to support research into transcriptional regulation. Sequence motifs representing transcription factor binding sites are usually encoded as position weight matrices. The user inputs a set of such weight matrices or binding site sequences and our program matches them against the T-Reg database, which is presently built on data from the Transfac [E. Wingender (2004) In Silico BioL, 4, 55-61] and Jaspar [A. Sandelin, W. Alkema, P. Engstrom, W. W. Wasserman and B. Lenhard (2004) Nucleic Acids Res., 32, D91-D94]. Our tool delivers a detailed report on similarities between user-supplied motifs and motifs in the database. Apart from simple one-to-one relationships, T-Reg Comparator is also able to detect similarities between submatrices. In addition, we provide a user interface to a program for sequence scanning with weight matrices. Typical areas of application for T-Reg Comparator are motif and regulatory module finding and annotation of regulatory genomic regions. T-Reg Comparator is available at http://treg.molgen.mpg.de.
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机译：T-Reg比较器是一种新颖的软件工具，旨在支持转录调控研究。代表转录因子结合位点的序列基序通常被编码为位置权重矩阵。用户输入一组这样的权重矩阵或结合位点序列，我们的程序将它们与T-Reg数据库进行匹配，该数据库目前基于Transfac [E. Wingender（2004）在Silico BioL，4，55-61]和Jaspar [A. Sandelin，W. Alkema，P. Engstrom，W. W. Wasserman and B. Lenhard（2004）Nucleic Acids Res。，32，D91-D94]。我们的工具提供了有关用户提供的图案与数据库中图案之间相似性的详细报告。除了简单的一对一关系外，T-Reg比较器还能够检测子矩阵之间的相似性。此外，我们为程序提供了一个用户界面，用于使用权重矩阵进行序列扫描。 T-Reg比较器的典型应用领域是主题和调控模块发现以及调控基因组区域的注释。 T-Reg比较器可从http://treg.molgen.mpg.de获得。
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