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GlyProt: in silico glycosylation of proteins

机译:GlyProt:蛋白质的计算机糖基化

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摘要

GlyProt (http://www.glycosciences.de/glyprot/) is a web-based tool that enables meaningful N-glycan conformations to be attached to all the spatially accessible potential N-glycosylation sites of a known three-dimensional (3D) protein structure. The probabilities of physicochemical properties such as mass, accessible surface and radius of gyration are calculated. The purpose of this service is to provide rapid access to reliable 3D models of glycoproteins, which can subsequently be refined by using more elaborate simulations and validated by comparing the generated models with experimental data.
机译:GlyProt(http://www.glycosciences.de/glyprot/)是基于网络的工具,可将有意义的N-聚糖构象附着到已知三维(3D)的所有空间可访问的潜在N-糖基化位点上蛋白质结构。计算了诸如质量,可及表面和回转半径之类的理化特性的概率。该服务的目的是提供对糖蛋白可靠3D模型的快速访问,随后可以通过使用更精细的模拟对其进行完善,并通过将生成的模型与实验数据进行比较来进行验证。

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