The MAGIC Study and the gastrointestinal effects of low-dose aspirin : editorial to: 'Prospective cohort study of gastrointestinal complications and vascular diseases in patients taking aspirin: rationale and design of the MAGIC Study' by H. Origasa et al.

摘要

In this edition of Cardiovascular Drugs and Therapy, Origasa and colleagues describe the rationale and design of the MAGIC Study, a large Japanese cohort study designed to assess the frequency of gastrointestinal complications associated with low-dose aspirin therapy [1]. Bleeding, particularly from the gastrointestinal tract is the most important adverse effect of aspirin but its frequency and consequences have not been well studied. In most large scale randomised trials the focus has been on the potential benefits with less rigorous assessment of the negative consequences of therapy.