Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model

Rossello Xavier; Burke Niall; Stoppe Christian; Bernhagen Jurgen; Davidson Sean M.; Yellon Derek M.

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Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model

机译：在生理浓度外源重组MIF未能减轻Langendorff灌注离体小鼠心脏模型中的梗死面积

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摘要

Evidence suggests a two-pronged role of endogenous macrophage migration inhibitory factor (MIF) release in ischemia/reperfusion injury. We aimed to assess whether its exogenous administration confers cardioprotection.

机译：有证据表明内源性巨噬细胞迁移抑制因子（MIF）释放在缺血/再灌注损伤中起两方面的作用。我们旨在评估其外源性给药是否赋予心脏保护作用。

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《Cardiovascular drugs and therapy》 |2016年第5期|共9页
作者
Rossello Xavier; Burke Niall; Stoppe Christian; Bernhagen Jurgen; Davidson Sean M.; Yellon Derek M.;
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正文语种 eng
中图分类药学;
关键词
Ischemic preconditioning; Ischemia-reperfusion; Myocardial infarction; Macrophage migration inhibitory factor;

机译：缺血预处理;缺血再灌注;心肌梗塞;巨噬细胞迁移抑制因子;

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1. Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model [J] . Rossello Xavier, Burke Niall, Stoppe Christian, Cardiovascular drugs and therapy . 2016,第5期

机译：在生理浓度外源重组MIF未能减轻Langendorff灌注离体小鼠心脏模型中的梗死面积
2. Effects of direct sympathetic and vagus nerve stimulation on the physiology of the whole heart--a novel model of isolated Langendorff perfused rabbit heart with intact dual autonomic innervation. [J] . Ng GA ham.ac.uk, Brack KE, Coote JH Experimental Physiology . 2001,第3期

机译：直接交感神经和迷走神经刺激对整个心脏生理的影响-一种具有完整的双重自主神经支配的孤立的Langendorff灌注兔心脏的新型模型。
3. Pretreatment with insulin before ischaemia reduces infarct size in Langendorff-perfused rat hearts. [J] . Fuglesteg BN, Tiron C, Jonassen AK, Acta physiologica . 2009,第2期

机译：缺血前用胰岛素预处理可减少灌注Langendorff大鼠心脏的梗塞面积。
4. Dichotomic Effects Of Diazoxide And Cyclosporin A On Contractile Function And Infarct Size In Langendorff Perfused Rat Hearts [C] . Mirica N., Luculescu M., Raducan A., International Congress on Coronary Artery Disease . 2009

机译：二氮氧化物和环孢菌素A对Langendorff灌注大鼠心脏收缩函数和梗塞大小的二分效应
5. The application of an isolated perfused working heart model to the design of endocardial pacing systems [D] . Laske, Timothy Gerard 2004

机译：离体灌注工作心脏模型在心内膜起搏系统设计中的应用
6. Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model [O] . Xavier Rossello, Niall Burke, Christian Stoppe, -1

机译：在生理浓度的外源性重组MIF给药未能减轻Langendorff灌注离体小鼠心脏模型中的梗死面积
7. Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model [O] . Rossello, Xavier, Burke, Niall, Stoppe, Christian, 2016

机译：在生理浓度的外源性重组MIF给药未能减轻Langendorff灌注离体小鼠心脏模型中的梗死面积

Exogenous Administration of Recombinant MIF at Physiological Concentrations Failed to Attenuate Infarct Size in a Langendorff Perfused Isolated Mouse Heart Model

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