Nitrosyl iron complexes with enhanced NO donating ability: synthesis, structure and properties of a new type of salt with the DNIC cations [Fe(SC(NH2)(2))(2)(NO)(2)](+)

摘要

Novel nitrosyl iron complexes [Fe(SC(NH2)(2))(2)(NO)(2)](2)SO4 center dot H2O(I) and [Fe(SC(NH2)(2))(2)(NO)(2)](2)[Fe-2(S2O3)(2)(NO)(4)](II) have been synthesized via the reactions of FeSO4 and Na-2[Fe-2(S2O3)(2)(NO)(4)], respectively, with acidic solutions of thiocarbamide in water. The structure and properties of I and II were studied using X-ray analysis, Mossbauer, IR, and EPR spectroscopy and amperometry. Both complexes are characterized by a prolonged NO generation without additional activation in aqueous anaerobic solutions, similar to the organic NO donor diethylene triamine; however, they are more effective: at pH 7 the NO amount is similar to 32.6 and similar to 31.8 nM mol(-1) of the complex for I and II, respectively. The obtained results show feasibility for the synthesis of water-soluble hybrid nitrosyl NO-generating complexes, which contain the NO groups both in the cationic and anionic sublattices and provide the control of the NO release kinetics.