The Regulatory Influence of Galarmin on the Level and Activity of Rat Tissue Metalloproteins after Doxorubicin-induced Nephro- and Cardiotoxicity

摘要

Doxorubicin (DR) is a potential antineoplastic drag that is used for therapy of different types of malignant tumors (leukemia, lymphoma, mammary tumor, lung, ovarian, pancreatic tumor etc.). However, the long-term use of DR leads to irreversible cardiomyopathy and nephropathy due to DR-induced formation of free oxygen radicals that disturb the functionality of the mitochondria, membranes, and nuclei of cells. The mechanisms of DR-induced cardiotoxicity and nephrotoxicity associated with changes in the activity of antioxidant metalloproteins (Cu, Zn-SOD, Mn-SOD, and catalase) and prooxidant metalloproteins (acidic isoforms of cytochrome (cyt) b_(558) and cyt C) in heart and kidney cells are not clear. Here we tried to evaluate these biochemical factors.