Surface-Modified Superparamagnetic Iron-Oxide Nanoparticles

摘要

The generation of superparamagnetic iron-oxide nanoparticles bearing fluorescent ligands is described.gamma-Fe2O3 nanoparticles(radius approx 4 and 8nm)bearing octylamine or oleic acid as ligands were prepared by hydrothermal synthesis starting from Fe-cupferron and iron pentacarbonyl,respectively.Ligand exchange proceeds with 1,2-diols bearing omega-azido or omega-bromo ligands at elevated temperatures.Subsequent nucleophilic substitution reaction,followed by 1,3-dipolar cycloaddition reactions with 2,4,6-trinitro-1-O-propargyl-ben-zene yields superparamagnetic iron-oxide nanoparticles with a fluoresecent ligand on their surface.