Direct asymmetric aldol reaction of cyclohexanone with aldehydes catalyzed by chiral trans-cyclohexanediamine L-tartrate salt

摘要

The stable and commercially available catalyst (1R,2R)-(+)-l,2-cyclohexanediarnine L-tartrate complex was used for asymmetric aldol reaction in high yields (up to 99 %) and enantioselectivities [up to 94 % enantiomeric excess (ee)]. The catalyst was obtained easily and reused three times.