METHOD FOR PRODUCING ASYMMETRIC CATALYZED ALDOL REACTION PRODUCT

摘要

PROBLEM TO BE SOLVED: To provide a method for producing an asymmetric catalyzed aldol reaction product capable of producing an aldol compound in high asymmetric yield by using acetaldehyde as a nucleophilic agent in the asymmetric catalyzed aldol reaction between an aldehyde and an aldehyde.;SOLUTION: An asymmetric catalyst represented by general formula (2) or its enantiomer is used as an asymmetric catalyst in an asymmetric catalyzed aldol reaction. In the formula, R² and R³ are each independently an aryl group, a heteroaryl group, a cycloalkyl group, a heterocycloalkyl group, a cycloalkenyl group, a heterocycloalkenyl group, an alkyl group, an alkenyl group or an alkynyl group which may have substituents; R⁴ is a hydrogen atom, a silyl group or an alkyl group; R⁵ is a protective group for a hydroxyl group; and n is 0 or 1.;COPYRIGHT: (C)2009,JPO&INPIT