Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis

Bharucha A. E.; Daley S. L.; Low P. A.; Gibbons S. J.; Choi K. M.; Camilleri M.; Saw J. J.; Farrugia G.; Zinsmeister A. R.

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Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis

机译：血红素对糖尿病胃轻瘫血红素加氧酶-1，胃排空和症状的影响

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BackgroundTherapeutic options for management of diabetic gastroparesis are limited. Failure to maintain upregulation of heme oxygenase (HO1) leads to loss of interstitial cells of Cajal and delayed gastric emptying (GE) in non-obese diabetic mice. Our hypothesis was that hemin upregulation of HO1 would restore normal GE in humans with gastroparesis.

机译：背景技术治疗糖尿病性胃轻瘫的治疗选择有限。无法维持血红素加氧酶（HO1）的上调导致非肥胖糖尿病小鼠的Cajal间质细胞丢失和胃排空延迟（GE）。我们的假设是，HO1的血红素上调将恢复胃轻瘫患者的正常GE。

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《Neurogastroenterology and motility》 |2016年第11期|共10页
作者
Bharucha A. E.; Daley S. L.; Low P. A.; Gibbons S. J.; Choi K. M.; Camilleri M.; Saw J. J.; Farrugia G.; Zinsmeister A. R.;
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正文语种 eng
中图分类消化系及腹部疾病;
关键词
heme oxygenase; hemin; HO1; humans;

机译：血红素加氧酶;血红素;HO1;人类;

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1. Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis [J] . Bharucha A. E., Daley S. L., Low P. A., Neurogastroenterology and motility . 2016,第11期

机译：血红素对糖尿病胃轻瘫血红素加氧酶-1，胃排空和症状的影响
2. Non-diabetic patients with gastroparesis-like symptoms assessed with gastric emptying scintigraphy and wireless motility capsule [J] . Neurogastroenterology and motility . 2019,第S4期

机译：非糖尿病患者胃瘫患者样症状评估胃排空的闪烁和无线运动胶囊
3. The relation between symptom improvement and gastric emptying in the treatment of diabetic and idiopathic gastroparesis [J] . JanssenP., ScottHarrisM., JonesM., The American Journal of Gastroenterology . 2013,第9期

机译：糖尿病和特发性胃轻瘫的症状改善与胃排空的关系
4. Pegylated hemin, a water-soluble micelle with therapeutic potential against ischemia-reperfusion injury via induction of heme oxygenase-1 [C] . Jun Fang, Haibo Qin, Takahiro Seki, Annual meeting exposition of the Controlled Release Society . 2011

机译：聚乙二醇化的血红素，一种水溶性胶束，具有通过诱导血红素加氧酶-1对抗缺血再灌注损伤的治疗潜力
5. Effects of high-fat vs. high-carbohydrate diets on proximal gastric relaxation, gastric emptying, pH of gastric contents and plasma cholecystokinin in the horse [D] . Lorenzo-Figueras, Mireia 2004

机译：高脂和高碳水化合物饮食对马近端胃松弛，胃排空，胃内容物pH和血浆胆囊收缩素的影响
6. Effects of Hemin on Heme Oxygenase-1 Gastric Emptying and Symptoms in Diabetic Gastroparesis [O] . Adil E. Bharucha, Shannon L. Daley, Phillip A Low, -1

机译：血红素对糖尿病性胃轻瘫患者血红素加氧酶-1胃排空和症状的影响
7. Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis [O] . A. E. Bharucha, S. L. Daley, P. A. Low, 2016

机译：血红素对糖尿病胃病血红素氧酶-1，胃排空和症状的影响
8. Structure-Activity Relationships in the Cytoprotective Effect of Caffeic Acid Phenethyl Ester (CAPE) and Fluorinated Derivatives: Effects on Heme Oxygenase-1 Induction and Antioxidant Activities. [R] . Wang, X., Stavchansky, S., Kerwin, S. M., 2010

机译：咖啡酸苯乙酯（CapE）和氟化衍生物的细胞保护作用中的构效关系：对血红素氧合酶-1诱导和抗氧化活性的影响。

Effects of hemin on heme oxygenase-1, gastric emptying, and symptoms in diabetic gastroparesis

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